Titans vs. Colts Odds: Tennessee Is a Favorite Week 3 Against Indianapolis

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The Tennessee Titans play their AFC South rival Indianapolis Colts twice in 2025, once in Week 3 and again in Week 8. 

Key Takeaways

  • The Titans will host the Colts in Week 3 at Nissan Stadium in Nashville, Tennessee. 
  • The Titans are favored to beat the Colts, as they are -1.5-point favorites in their Week 3 showdown with the Colts.

Here you'll find the best odds and lines for Titans vs. Colts found at Tennessee sportsbooks.

Titans vs. Colts: Who is Favored to Win?

The Titans are currently 1.5-point favorites to beat the Colts in Week 3, meaning they must win by at least two points to cover the spread at home. 

TeamTitansColts
Spread-1.5 (-110)+1.5 (-110)
Total45.5 (O)45.5 (U)
Moneyline-125+105

What The Spread Tells Us

The spread indicates that this game is likely to come down to the wire. Oddsmakers believe the Titans will be the team that likely wins this game, even if it is not with supreme confidence. 

What The Moneyline Tells Us 

The moneyline indicates that the Titans are the favorites; it's an extremely slim moneyline. If you were to bet $100 on the Titans, then you would get $80 back plus the $100 you bet. Likewise, you would get $105 back plus the original $100 if you bet on the Titans. 

How The Titans Win vs. The Colts

The Titans can win against the Colts if Cam Ward can find his touch and some open receivers. Then, they need Tony Pollard to run the ball efficiently. On defense, the Titans need to contain Daniel Jones and put some pressure on him. 

How The Colts Win vs. The Titans

The Colts can beat the Titans by establishing the lead early. To do this, they need Jones to make smart plays, either with his arm or his legs. They also need Jonathan Taylor to run the football well. On defense, DeForest Buckner needs to break through the line, and disrupt Ward. Charvarius Ward must lock things down in the secondary. 

History of Titans vs. Colts

The Colts and Titans have engaged in a divisional rivalry since the realignment. The feud has seen some epic battles that have featured legends like Peyton Manning and Eddie George, as well as great talent like Andrew Luck. 

The Titans and Colts have played each other 61 times, dating back to 1970 when the teams were named the Houston Oilers and Baltimore Colts, respectively. These two teams only played each other every once in a while from 1970 to 2001, when the Titans/Oilers were in the AFC Central and the Colts were in the AFC East. Starting in 2002, these teams moved to the AFC South and began to face each other twice a year.

Here are the most important facts related to odds for the TEN vs. IND Week 3 matchup. You can find odds on many of the available TN betting apps.

Titans Record vs. Colts

The Colts lead the head-to-head series 39-22, meaning the Titans have some work to do. The Colts have won four games in a row in this series. Prior to that, the Titans had won five consecutive games. 

Neither team is in a good spot right now. However, the line is very close, as oddsmakers believe it will be a tight battle. 

Odds via DraftKings Sportsbook.

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How to Watch Titans vs. Colts

The Titans vs. Colts Week 3 game will air on CBS in local markets at noon CT/1 p.m. ET. Out-of-market fans can catch the game on NFL Sunday Ticket, which is exclusively on YouTube TV.

Tennessee Titans quarterback Will Levis (8) scrambles and jumps over Indianapolis Colts linebacker E.J. Speed (45), linebacker Zaire Franklin (44) and cornerback Kenny Moore II (23), on Sunday, Dec. 3, 2023, during NFL week 13 at Nissan Stadium in Nashville, Tenn.

Most Recent Matchup

The last game between the Titans and Colts was played on December 22, 2024. The Colts won that game 38-30 at Lucas Oil Stadium. 

Top 5 Games

DateMatchupWinner
Dec. 3, 2023IND @ TENColts 31-28
Oct. 31, 2021TEN @ INDTitans 34-31
Jan. 2, 2011TEN @ INDColts 23-20
Dec. 3, 2006IND @ TENTitans 20-17
Jan. 16, 2000*TEN @ INDTitans 19-16

* = playoff game

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Author

Wes Roesch

Wes is an editor and writer for BetTennessee.com. Based out of the Kansas City area, Wes has covered sports professionally since 2015 with a strong emphasis on sports betting and the NFL, though he's also covered pro wrestling, UFC, college sports and more.